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Safety Results: Crop Protection Products

Here you will find study summaries concerning the human and environmental safety of many of our active substances that have been evaluated by the European Food Safety Authority (EFSA). You will also have on-demand, non-commercial access to the full safety study reports behind these summaries. This list is updated on a rolling basis to allow for access to safety-related information while new materials are prepared for release. We will continuously add information, including studies from around the world.



Terms and Conditions

The download of study summaries is subject to our Terms and Conditions for Access to Crop Protection Active Substances, Crop Protection Products and GM seeds and traits Study Documents. Any use of Study Documents or their content for regulatory or any other commercial purpose is prohibited. Distribution, reproduction and/or publication can be subject to consent.


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( *) For these substances in the selection list, full study reports can already be ordered via hyperlinks in the safety study documents)




Ripe grapes sunshine

Fenhexamid, a fungicide known under Bayer’s brand name Teldor*, has been delivering Botrytis control on a variety of fruits and vegetables including grapes and soft fruits for almost two decades now. Fenhexamid is a crucial alternation partner in disease resistance management programs and is best used in a preventative program. It inhibits the germ tube growth and prevents the penetration of the fungus into the plant tissue resulting in effective and long-lasting protection.


Active Substance: fenhexamid
Formulation: fenhexamid WG 50 (500 g/kg)

Fluoxastrobin is a systemic strobilurin fungicide that provides broad-spectrum disease control and excellent plant health properties. The compound can be applied as foliar fungicide, primarily in combination with other Bayer proprietary fungicides, or as a seed treatment. Core target crops are cereals, corn, potatoes and vegetables. The major brand for foliar application is Fandango®, for seed treatment application Scenic®.



Active Substance: fluoxastrobin


Formulation: bixafen + fluoxastrobin + prothioconazole EC 190 (40+50+100 g/L)
Formulation: fluoxastrobin + prothioconazole EC 200 (100 + 100 g/l)

Fosetyl, known under the major brand Aliette, is a Plant Natural Defence enhancer: Fosetyl based solutions slow down significantly the invasion of the pathogen by reinforcing the defensive reactions of the plants, sealing-off the invading organism. With such a unique mode of action, it is highly unlikely to face resistance development. Thanks to its specific bioavailability properties new shoots, new growths of the plants are also protected. Fosetyl solutions are used worldwide, mostly in Grapes, but also Citrus, Pome fruits, Solanacees, Berries and a number of other fruits and vegetables, for the protection they provide against major fungal and bacterial diseases.


Active Substance: fosetyl-aluminium


Formulation: fosetyl-aluminium + fluopicolide WG 71.11 (666.7 + 44.4 g/kg)


Formulation: fosetyl-aluminium WG 80 (800 g/kg)

Iprovalicarb, known under the major Melody brand, is a fungicide used on Grapes, Potatoes and Tomatoes mainly, to protect those crops from Downy Mildew & Late Blight losses (these diseases could result in 80-100% harvest loss). Iprovalicarb combines excellent control of oomycete fungi with high plant compatibility and shows a strong potency in controlling infections that have just occurred (24-48h before), providing the flexibility to the growers to catch up a dangerous situation when they were in no position to prevent it due to circumstances out of his control (weather, organizational constraints… ).


Active Substance: iprovalicarb


Formulation: iprovalicarb + folpet WG 65.3 (90+563 g/kg)
Wheat plants on top of wheat seeds

Isoflucypram is the most recent innovative fungicide from Bayer’s crop protection pipeline. It shows excellent efficacy against a broad variety of cereal diseases, like leaf spots and rusts. Untreated those diseases are strongly affecting the quality and yield of cereal growers world-wide, yield losses of up to 40% are possible. Despite its low application rate, Isoflucypram offers long-lasting protection and unmatched yield security to our customers.


Active Substance: isoflucypram


Formulation: isoflucypram EC 50 (50 g/L)

Propineb known under the major brand Antracol® is one of the three big multi-site fungicides in the world, mainly for application in horticulture as well as in rice in more than 50 countries in Asia and Latin America. Besides the fungicidal activity against Anthracnosis and Leaf spots, Propineb’s Zinc content results in a plant strengthening, visible greening effect. Multi-sites like Antracol® are part of Bayer’s resistance management programs and to close portfolio gaps.


Active Substance: propineb


Formulation: propineb WG 70 (700g/kg)

Prothioconazole known under the major brands Prosaro®, Proline® and Fox®, is one of the largest crop protection assets at Bayer, considered an internal blockbuster and the most important DMI fungicide for growers around the world in controlling the most devastating fungal diseases in their crops. Prothioconazole is registered in over 60 countries and offers unprecedented control of Fusarium head blight (FHB) in cereals, and is the best performing DMI fungicide against the largest fungal pathogen Asian Soybean Rust (ASR) in soybeans. It is also considered a foundational mixture partner and necessary resistance management tool.


Active Substance: prothioconazole
Formulation: bixafen + prothioconazole EC 225 (75 + 150 g/l)


Formulation: prothioconazole FS 100 (100 g/l)

Many Trifloxystrobin-containing products are marketed in more than 100 countries and in all major crop groups. The broad range of diseases which are controlled by these products, the additional beneficial plant physiological effects as well as the high crop safety make Trifloxystrobin a multipurpose asset for farmers. Today Trifloxystrobin is used extensively in soybean with the brands Fox, Cripton and Delaro, followed by Horticulture with the brand Nativo.


Active Substance: trifloxystrobin


Formulation: trifloxystrobin WG 50 (500g/kg)



Deltamethrin is an insecticide and protects a wide range of crops globally including cereals, vegetables, fruits and ornamentals, grown in open field and/or under protection against many important pests causing economic damage. Deltamethrin is used in agriculture, timber protection, vector control and more. Deltamethrin is a non-systemic insecticide which acts on the insect by contact and ingestion. Deltamethrin is not systemic within plants.



Active Substance: deltamethrin


Formulation: deltamethrin EW 15 (15 g/l)

Flupyradifurone known under the major brand SIVANTO® is the latest sucking insecticide in Bayer’s crop protection portfolio for worldwide use. This innovative compound is primarily for use in a wide variety of fruit and vegetable crops as well as plantation (citrus, coffee, cocoa), tropical fruits and defined broad acre crops. It performs well against a large spectrum of mostly sucking pests including aphids, whiteflies, psyllids, scales, scirtothrips, leafhoppers, mealy bugs, coffee leaf miner, lygus bugs and cocoa mirids. SIVANTO® meets the diverse safety needs in modern applied agriculture and fulfills today’s regulatory requirements for an IPM (Integrated Pest Management) friendly insecticide.


Active Substance flupyradifurone


Formulation flupyradifurone SL 200

Imidacloprid known under the major brands Confidor®, Admire® for foliar or soil application or Gaucho® for seed treatment is our leading insecticide from the group of neonicotinoids. This chemical class revolutionized pest management on farms by replacing several sprays of older chemistry. Imidacloprid provides as soil-applied insecticide many benefits. The active substance is taken up by the plant to protect it from inside against attacks from harmful insects. Farmers around the world value the product in a wide range of crops with a broad spectrum of efficacy.


Imidacloprid Bee reports *)
Spirotetramat Movento

Spirotetramat, under the major brand MOVENTO®, is a unique insecticide of the ketoenol family that acts against a broad range of sucking insect pests, including scales, mealybugs, psylla, aphids, phylloxera, and whiteflies. MOVENTO® is primarily used in intensively grown crops like fruits and vegetables. With its unique mode of action, that once inside the leaf has a two-way systemicity moving to all areas of the plant, including new shoot, leaf and root tissues, it offers long-lasting efficacy and an excellent tool for resistance management and Integrated Pest Management (IPM).


Active Substance spirotetramat


Formulation spirotetramat OD 150

Thiacloprid known under the major brand Biscaya® or Calypso® is a neonicotinoid insecticide with a favorable bee safety profile. It is therefore especially used by oilseed rape farmers to control harmful insects in this highly bee attractive crop. Also fruit and vegetable & potato farmers value thiacloprid for controlling a wide range of sucking insects, but thiacloprid also effectively controls the lepidoperan pest codling moth. In cereals, the same as in the other crops, thiacloprid is an important part of the rotation of products with different modes of action to ensure sustainable pest management and follow resistance management guidelines.


Active Substance: thiacloprid


Formulation: thiacloprid FS 400 (400 g/l)


Formulation: thiacloprid OD 240 (240 g/l)



Amidosulfuron is the component of brands like Gratil®, Hoestar®, Sekator® and Pacifica® Plus. It is used in cereals and pastures to control broadleaved weeds particularly Galium aparine, the most competitive dicot weed in European cereals and Rumex in pastures. Amidosulfuron belongs to the group of sulfonyl urea herbicides and is part of Bayer´s Integrated Weed Management program to maximize yield protection and to ensure sustainable future weed control for growers.


Active Substance: amidosulfuron


Formulation: amidosulfuron WG 75

Ethephon is an important active ingredient used for plant growth regulation and registered in over 40 countries around the word. Important brands are Cerone®, Finish® and Ethrel®. Ethephon is a systemic plant growth regulator belonging to the phoshonate family. It is fastly absorbed by the plant and releases ethylene which is a natural plant hormone. Ethylene influences directly several physiological processes (i.e. ripening, maturation) and stimulates the production of endogenous ethylene. Ethephon is taking up by the leaves and is transported to the vegetal tissues and translocated from the leaves to the plant tissues. Progressively, it is transformed into ethylene in the plant, modifying the growth processes stimulating the synthesis of phenol and lignine.


Ethephon is used in cereals (wheat, barley, rye and triticale) to increase resistance to lodging through straw shortening and strengthening. On fruits and vegetables to promote fruit maturity (early and uniform ripening and coloring of mature fruits), on ornamentals to stimulate flowering and side branching and to reduce plant height. On cotton to promote uniform boll opening and enhance defoliation.


Active Substance: ethephon


Formulation: ethephon SL 480 (480 g/l)

When it comes to pre-emergence and early-post control of key grass weeds in cereals, Flufenacet is the farmers’ first choice. It offers excellent control of the most problematic weeds, especially grass weeds like Alopecurus (blackgrass), Lolium (ryegrass) and Apera species. Flufenacet is a key component of brands like Cadou®, Fosburi®, Liberator® and Bacara Forte®. As the key active ingredient for autumn applications, Flufenacet is part of Bayer`s Integrated Weed Management offering, providing farmers with agronomic solutions for optimized weed control and maximum yield protection.


Active Substance: flufenacet


Formulation: diflufenican+flufenacet SC600 (200+400)G

Flurtamone is a key ingredient of the products that farmers know as Bacara Forte®, Carat®, Movon® and Vigon®. It is an important cereal herbicide for pre-emergence and early-post control of key weeds, particularly Apera species, e.g. Apera spica-venti. Farmers use it for different types of cereals, including wheat, barley, rye and triticale. With the goal of enhancing farmer`s productivity, Fluratmone is an important element of Bayer`s Integrated Weed Management offering, resulting in customized agronomic solutions for optimized weed control and maximum yield protection. Image from News section.


Active Substance: flurtamone


Formulation: diflufenican + flurtamone SC 350 (100+250 g/L)

Foramsulfuron is a compound which is already successfully used in corn for many years. It controls a broad spectrum of important annual and perennial grass weeds and broadleaved weeds. Foramsulfuron is one of the most effective active ingredients for the control of Sorghum halapense. It is mainly used between 3 leave and five leave stage of corn. Important brand names are Monsoon/Equipe, Monsoon active (combination with Thiencarbazone-methyl, MaisTer (combination with Iodosulfuron-methyl)/MaisTer power (combination with Iodosulfuron-methyl and Thiencarbazone-methyl).


In addition to corn, the active has been launched 2018 in sugar beets in the first countries in Europe. In combination with Thiencarbazone-methyl (Brand name CONVISO one) Formsulfuron is part of an innovative system for the weed control in sugar beets that are tolerant to this mode of action. By using this system the farmer can reduce the number of his herbicides treatments used today by approx. 50%.


Active Substance: foramsulfuron


Formulation: foramsulfuron + isoxadifen-ethyl OD 45 (22.5 + 22.5 g/l)

Glyphosate is a versatile herbicide that has been used for more than 40 years by farmers, land managers, gardeners, and others to simply, safely, and effectively control problematic weeds. Since the introduction in 1974, glyphosate-based products have become the most commonly used herbicides in the world because of the ability to control a broad spectrum of weeds, the extensive economic and environmental benefits, and the strong safety profile. In the 1990s, combining glyphosate with crops that could withstand applications of this herbicide transformed agriculture in many parts of the world and modern agriculture biotechnology began. Our portfolio of glyphosate-based products will continue to be a very important part of our integrated weed management (IWM) offerings.


Active Substance: glyphosate


Formulation: 360 g/L glyphosate acid


Glyphosate active substance and formulation: Access to full Bayer-owned study reports

Iodosulfuron-methyl-sodium is a sulfonylurea herbicide for post-emergence use mainly in cereals and corn. It is effective against grass weeds e.g. Apera spica-venti, Lolium ssp., Phalaris spp. and as well as a wide range of broadleaved weeds e.g. Cirsium arvense, Galium aparine, Lamium spp., Matricaria chamomilla Stellaria media etc. .Iodosulfuron is a key component of brands like Hussar®, Sekator® and Atlantis®. It is an integral part of Bayer`s Integrated Weed Management program providing farmers with agronomic solutions for optimized weed control and maximum yield protection.


Active Substance: Iodosulfuron-methyl-sodium

Formulation: Idosulfuron-methyl-sodium + mefenpyr-deithyl OD 400 (100 +300 g/l)

Isoxaflutole is a herbicide compound that has been successfully used for over 20 years and is the backbone of our portfolio in corn and sugarcane in Europe, North America and Latin America.


During the early phases of the development, corn reacts very sensitive on weed competition: Isoxaflutole which can be used in this early phase from pre-emergence of corn until 3 leaf stage. The compound has a very strong residual efficacy and is able to provide a season control of a number of the most important annual grasses (e.g. Echinochloa species) and annual broadleaved weeds. To complete the weed spectrum Isoxaflutole is used in tank mixture with other herbicides. After a longer-lasting period of drought, the compound can be reactivated after rainfall within 4 weeks after application.


Important brand names are in Corn are Merlin®/ Balance® and Merlin®flexx/ Balance®flexx (combination with the Safener Cyprosulfamide), Adengo®/ Corvus® (combination with Thiencarbzone-methyl and Cyprosulfamide) and Lagon® (combination with Aclonifen). In sugarcane the lead brand is Provence®


Active Substance: isoxaflutole


Formulation: isoxaflutole + cyprosulfamide SC 480 (240 + 240 g/l)

Mesosulfuron-methyl known under the brand Atlantis® is one of the leading cereal herbicides for post-emergence Alopecurus myosuroides control strategies and further important grass weeds in wheat, rye and triticale. To enhance farmer’s productivity Mesosulfuron-methyl belongs to Bayer’s Integrated Weed Management programs delivering customized agronomic solutions for optimized weed control and maximum yield protection.



Active Substance: mesosulfuron


Formulation: iodosulfuron-methyl-sodium + mesosulfuron-methyl + mefenpyr-diethyl OD 42 (2+10+30 g/l)

Propoxycarbazone – sodium is the active ingredient of Bayer´s cereal herbicide Attribut®, which is applied post-emergence in wheat, rye and triticale to control several important grass weeds such as Alopecurus myosuroides, Apera spica-venti, hard to control Bromus species and the perennial grass weed Agropyron repens. To maximize performance and to ensure sustainable future grass-weed control Propoxycarbazone – sodium is part of Bayer´s Integrated Weed Management Program.



Active Substance: propoxycarbazone-sodium


Formulation: Attribute SG70 (700 g/kg propoxycarbazone-sodium)



Bacillus amyloliquefaciens strain QST 713, better known under the brand family of Serenade®, is the leading biological used against pathogenic organisms like fungi and bacteria. Based on a naturally occurring strain, Serenade is exempt from residues and can be applied until harvest time. So farmers use QST 713 as part of tailored solutions in order to reduce the chemical load or manage residues in Fruit and Vegetables. In bacterial disease management, Serenade® is an alternative to antibiotics and replaces coppers sprays.  Serenade® applied to the soil activates the plant growth to increased yield and harvest quality. The Serenade® brand family is registered for a wide range of crops and diseases and is commercial in over 50 countries globally. (note: Bacillus amyloliquefaciens strain QST 713 formerly known as Bacillus subtilis strain QST 713).


Active Substance: bacillus amyloliquefaciens strain QST 713
Formulation: Serenade ASO
Bayer biocontrol agents included in the Transparency Initiative

Contans WG, based on the natural occurring soil fungus Coniothyrium minitans, is a biological fungicide with specific antagonistic action against the remaining surviving structures (sclerotia) of the plant pathogens Sclerotinia spp. Best and sustainable results are achieved if Contans WG is strategically integrated into the crop rotation. In lettuce, for example, it is one of the best available tools controlling S. sclerotiorum.


Active Substance: coniothyrium minitans


Formulation: Contans WG (1 x 1012 CFU coniothyrium minitans/kg)

Purpureocillium lilacinum known under the tradename of BioAct is a fungal antagonist of nematodes. It is able to parasitize nematode eggs and thus lowering the nematode infestation level. BioAct, as a biological, is a valuable addition to any nematode control strategy. It supports further reductions of chemical use while keeping the nematode damage under control, especially in horticultural crops.


Active Substance: purpureocillium lilacinum


Formulation: BioAct WG, 1 x 1010 spores/gram (60 g/kg)
terpenoid blend

Terpenoid Blend, known under the name Requiem prime, is a biological insecticide that delivers fast knockdown to sucking pests in horticultural crops throughout the season to improve the efficacy of pest management programs and increase marketability. It does not affect beneficial & pollinators and helps managing resistance.

Active Substance: Terpenoid blend QRD 460
Formulation: Requiem EC (QRD 452)

Note: This website does not constitute a specific product advertisement, but only provides general comments and information to better understand the background of the study information offered on this website. As a result, the products which are mentioned are not registered in every country. National label instructions have to be read and followed. Use plant protection products safely. For further product information visit: